PIP2/YOR363C Summary

PIP2 BASIC INFORMATION

Standard Name	PIP2
Systematic Name	YOR363C
Alias	OAF2 1
Feature Type	ORF, Verified
Description	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes (2, 3)
Name Description	Peroxisome Induction Pathway 2

GO Annotations	All PIP2 GO evidence and references
	View Computational GO annotations for PIP2
Molecular Function
Manually curated	specific RNA polymerase II transcription factor activity (IDA, IMP) transcription activator activity (IMP)
Biological Process
Manually curated	fatty acid metabolic process (IMP) peroxisome organization (IMP) positive regulation of transcription (IMP, IPI)
Cellular Component
Manually curated	nucleus (IPI)

Mutant Phenotype	All PIP2 Phenotype details and references
Classical genetics
null	peroxisomal morphology: abnormal resistance to L-1,4-dithiothreitol: decreased resistance to tunicamycin: normal resistance to mercaptoethanol: decreased toxin resistance: increased utilization of carbon source: absent viable
Large-scale survey
null	viable

Interactions	PIP2 All interactions details and references
	11 total interaction(s) for 6 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-localization: 3 Reconstituted Complex: 2
Genetic Interactions	Dosage Rescue: 1 Phenotypic Suppression: 1 Synthetic Lethality: 1

Sequence Information

ChrXV:1023210 to 1020220 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2991	1023210..1020220	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005890

PIP2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PIP2

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
CDC7	Nomenclature conflict	OAF2 has been used in the literature to refer to both PIP2/YOR363C, which encodes a transcription factor involved in peroxisome proliferation, and CDC7/YDL017W, which encodes a serine/threonine kinase.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PIP2]

1)	Karpichev IV and Small GM (1998) Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Mol Cell Biol 18(11):6560-70
2)	Rottensteiner H, et al. (1996) Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae. EMBO J 15(12):2924-34
3)	Rottensteiner H, et al. (1997) A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Eur J Biochem 247(3):776-83

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