Standard Name	PIP2 (see Nomenclature conflict Note)
Systematic Name	YOR363C
Alias	OAF2 1
Feature Type	ORF, Verified
Description	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication (2, 3, 4)
Name Description	Peroxisome Induction Pathway 2

Chromosomal Location	ChrXV:1023212 to 1020222 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PIP2
Molecular Function
Manually curated	contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA)
Biological Process
Manually curated	cellular response to oleic acid (IPI) positive regulation of fatty acid beta-oxidation (IMP) positive regulation of transcription from RNA polymerase II promoter (IDA, IMP)
Cellular Component
Manually curated	nucleus (IPI)
High-throughput	integral to membrane (ISM)

Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	SPS18 mRNA accumulation: decreased SPS19 mRNA accumulation: decreased DCI1 mRNA accumulation: decreased peroxisomal morphology: abnormal resistance to mercaptoethanol: decreased resistance to tunicamycin: normal resistance to L-1,4-dithiothreitol: decreased resistance to capric acid: decreased toxin resistance: increased utilization of carbon source: absent viable
unspecified	POX1 mRNA accumulation: decreased FOX3 mRNA accumulation: decreased CTA1 mRNA accumulation: increased POX1 mRNA accumulation: increased lipid particle morphology: abnormal peroxisomal morphology: abnormal
Large-scale survey
null	competitive fitness: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	23 total interaction(s) for 17 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-localization: 3 Reconstituted Complex: 2
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 7 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:1023212 to 1020222 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2991 1023212..1020222 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005890