Standard Name	HAP5
Systematic Name	YOR358W
Feature Type	ORF, Verified
Description	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex (1, 2)
Name Description	Heme Activator Protein 2

Chromosomal Location	ChrXV:1010161 to 1010889 | ORF Map | GBrowse

	View Computational GO annotations for HAP5
Molecular Function
Manually curated	contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IC) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (ISA)
High-throughput	DNA binding (IPI)
Biological Process
Manually curated	carbon catabolite activation of transcription from RNA polymerase II promoter (IMP) regulation of cellular respiration (IGI)
Cellular Component
Manually curated	CCAAT-binding factor complex (IDA, IPI)

Binding motifs	Predicted HAP5 Binding Site Locations
	CCAAT 2 [Search intergenic regions for CCAAT]
Regulatory modules	predicted: stressResponse (433)
Resources	ScerTF | YeTFaSCo

Classical genetics
null	resistance to sirolimus: increased resistance to fenpropimorph: increased
Large-scale survey
null	acid pH resistance: decreased anaerobic growth: decreased competitive fitness: decreased dessication resistance: decreased haploinsufficient resistance to methyl methanesulfonate: increased resistance to fluconazole: increased resistance to hygromycin B: decreased resistance to wortmannin: increased resistance to sirolimus: increased resistance to mycophenolic acid: increased resistance to tunicamycin: increased resistance to ethanol: decreased resistance to camptothecin: decreased resistance to cycloheximide: decreased resistance to fenpropimorph: increased respiratory growth: decreased rate respiratory growth: absent stress resistance: increased utilization of carbon source: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	221 total interaction(s) for 166 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 2 Reconstituted Complex: 8 Two-hybrid: 9
Genetic Interactions	Negative Genetic: 164 Phenotypic Enhancement: 4 Positive Genetic: 19 Synthetic Growth Defect: 5 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:1010161 to 1010889 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..729 1010161..1010889 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005885