Standard Name	TYE7
Systematic Name	YOR344C
Alias	SGC1
Feature Type	ORF, Verified
Description	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression (1, 2, 3)
Name Description	Ty-mediated Expression

Chromosomal Location	ChrXV:978069 to 977194 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 199 cM

	View Computational GO annotations for TYE7
Molecular Function
Manually curated	sequence-specific DNA binding transcription factor activity (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	positive regulation of glycolysis (IGI, IMP) transcription, DNA-dependent (IDA)
Cellular Component
Manually curated	nuclear chromatin (IDA)

Binding motifs	Predicted TYE7 Binding Site Locations
	TCACGTG 4 [Search intergenic regions for TCACGTG] TCACGTGA 5 [Search intergenic regions for TCACGTGA] TCACGTGAY 6 [Search intergenic regions for TCACGTGAY] TCTGGCACACA 2 [Search intergenic regions for TCTGGCACACA]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to dimethyl sulfoxide: decreased stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	176 total interaction(s) for 159 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 3 Reconstituted Complex: 1 Two-hybrid: 119
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 28 Phenotypic Suppression: 1 Positive Genetic: 14 Synthetic Growth Defect: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:978069 to 977194 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 199 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..876 978069..977194 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005871