MRS2/YOR334W Summary Help

Standard Name MRS2 1
Systematic Name YOR334W
Feature Type ORF, Verified
Description Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns (2, 3)
Name Description Mitochondrial RNA Splicing 4
Chromosomal Location
ChrXV:944596 to 946008 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MRS2 GO evidence and references
  View Computational GO annotations for MRS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 73 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
71 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 10
  • Negative Genetic: 47
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 470
Molecular Weight (Da) 54,202
Isoelectric Point (pI) 10.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:944596 to 946008 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1413 944596..946008 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000005861
References cited on this page View Complete Literature Guide for MRS2
1) Wiesenberger G, et al.  (1992) The nuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo. J Biol Chem 267(10):6963-9
2) Gregan J, et al.  (2001) Mitochondrial Mg(2+) homeostasis is critical for group II intron splicing in vivo. Genes Dev 15(17):2229-37
3) Kolisek M, et al.  (2003) Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria. EMBO J 22(6):1235-44
4) Kreike J, et al.  (1986) Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae. Curr Genet 11(3):185-91