SNC2/YOR327C Summary Help

Standard Name SNC2 1
Systematic Name YOR327C
Feature Type ORF, Verified
Description Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Suppressor of the Null allele of CAP 1
Chromosomal Location
ChrXV:931081 to 930734 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SNC2 GO evidence and references
  View Computational GO annotations for SNC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Classical genetics
Large-scale survey
197 total interaction(s) for 124 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 19
  • Co-fractionation: 1
  • FRET: 2
  • PCA: 10
  • Reconstituted Complex: 22
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 9
  • Negative Genetic: 69
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 13
  • Synthetic Growth Defect: 10
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 18
  • Synthetic Rescue: 6

Expression Summary
Length (a.a.) 115
Molecular Weight (Da) 12,957
Isoelectric Point (pI) 9.28
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:931081 to 930734 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..348 931081..930734 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005854
References cited on this page View Complete Literature Guide for SNC2
1) Protopopov V, et al.  (1993) Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell 74(5):855-61
2) Grote E, et al.  (2000) Ordering the final events in yeast exocytosis. J Cell Biol 151(2):439-52
3) Paumet F, et al.  (2004) The specificity of SNARE-dependent fusion is encoded in the SNARE motif. Proc Natl Acad Sci U S A 101(10):3376-80
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Shanks SG, et al.  (2012) The Sec1/Munc18 Protein Vps45 Regulates Cellular Levels of Its SNARE Binding Partners Tlg2 and Snc2 in Saccharomyces cerevisiae. PLoS One 7(11):e49628