COT1/YOR316C Summary Help

Standard Name COT1 1
Systematic Name YOR316C
Feature Type ORF, Verified
Description Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description CObalt Toxicity 1
Chromosomal Location
ChrXV:907555 to 906236 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All COT1 GO evidence and references
  View Computational GO annotations for COT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 10 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
32 total interaction(s) for 24 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • PCA: 12
  • Protein-RNA: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 9
  • Phenotypic Enhancement: 2
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 439
Molecular Weight (Da) 48,154
Isoelectric Point (pI) 6.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:907555 to 906236 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1320 907555..906236 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000005843
References cited on this page View Complete Literature Guide for COT1
1) Conklin DS, et al.  (1992) COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Mol Cell Biol 12(9):3678-88
2) MacDiarmid CW, et al.  (2000) Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. EMBO J 19(12):2845-55
3) Li L and Kaplan J  (1998) Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. J Biol Chem 273(35):22181-7
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76