NOP58/YOR310C Summary Help

Standard Name NOP58 1
Systematic Name YOR310C
Alias NOP5 2
Feature Type ORF, Verified
Description Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA (1, 2, 3, 4)
Name Description NucleOlar Protein of 58 kDa 1
Chromosomal Location
ChrXV:898360 to 896825 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All NOP58 GO evidence and references
  View Computational GO annotations for NOP58
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
repressible
Large-scale survey
null
reduction of function
Resources
371 total interaction(s) for 197 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 307
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 18
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 19
  • Positive Genetic: 2
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 511
Molecular Weight (Da) 56,956
Isoelectric Point (pI) 9.74
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:898360 to 896825 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1536 898360..896825 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005837
References cited on this page View Complete Literature Guide for NOP58
1) Gautier T, et al.  (1997) Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol Cell Biol 17(12):7088-98
2) Wu P, et al.  (1998) Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. J Biol Chem 273(26):16453-63
3) Lafontaine DL and Tollervey D  (1999) Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability. RNA 5(3):455-67
4) Dragon F, et al.  (2002) A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417(6892):967-70