NOP58/YOR310C Summary

NOP58 BASIC INFORMATION

Standard Name	NOP58 1
Systematic Name	YOR310C
Alias	NOP5 2
Feature Type	ORF, Verified
Description	Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA (1, 2, 3, 4)
Name Description	NucleOlar Protein of 58 kDa 1

GO Annotations	All NOP58 GO evidence and references
	View Computational GO annotations for NOP58
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP)
Cellular Component
Manually curated	90S preribosome (IDA) box C/D snoRNP complex (IDA, IPI) nucleolus (IDA) small-subunit processome (IDA)

Mutant Phenotype	All NOP58 Phenotype details and references
Classical genetics
null	inviable
repressible	35S pre-rRNA accumulation: increased aberrant 23S rRNA processing intermediate accumulation: increased 32S rRNA processing intermediate accumulation: decreased 27SA2 rRNA processing intermediate accumulation: decreased mature 18S rRNA accumulation: decreased snR52 precursor accumulation: increased snR33 accumulation: increased box C/D snoRNA construct derived from U14 (snR128) localization: abnormal
Large-scale survey
null	inviable

Interactions	NOP58 All interactions details and references
	192 total interaction(s) for 100 unique genes/features.
Physical Interactions	Affinity Capture-MS: 168 Affinity Capture-Western: 6 Reconstituted Complex: 2 Two-hybrid: 11
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Lethality: 4

Sequence Information

ChrXV:898357 to 896822 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1536	898357..896822	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005837

NOP58 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NOP58

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NOP58]

1)	Gautier T, et al. (1997) Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol Cell Biol 17(12):7088-98
2)	Wu P, et al. (1998) Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. J Biol Chem 273(26):16453-63
3)	Lafontaine DL and Tollervey D (1999) Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability. RNA 5(3):455-67
4)	Dragon F, et al. (2002) A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417(6892):967-70

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