SNU66/YOR308C Summary Help

Standard Name SNU66 1
Systematic Name YOR308C
Feature Type ORF, Verified
Description Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 (2, 3, 4)
Name Description Small NUclear ribonucleoprotein associated 2
Chromosomal Location
ChrXV:896387 to 894624 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SNU66 GO evidence and references
  View Computational GO annotations for SNU66
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
overexpression
Resources
295 total interaction(s) for 155 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 117
  • Affinity Capture-Western: 13
  • Co-crystal Structure: 1
  • Co-purification: 3
  • Protein-RNA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 102
  • Phenotypic Enhancement: 1
  • Positive Genetic: 19
  • Synthetic Growth Defect: 16
  • Synthetic Lethality: 8
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 587
Molecular Weight (Da) 66,429
Isoelectric Point (pI) 6.79
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:896387 to 894624 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1764 896387..894624 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005835
References cited on this page View Complete Literature Guide for SNU66
1) Mao C, et al.  (1999) The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem J 342 Pt 3():667-75
2) Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31
3) Stevens SW, et al.  (2001) Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae. RNA 7(11):1543-53
4) Li Z, et al.  (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213