Standard Name	RRS1
Systematic Name	YOR294W
Feature Type	ORF, Verified
Description	Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice (1, 2, 3, 4, 5)
Name Description	Regulator of Ribosome Synthesis 1

Chromosomal Location	ChrXV:868340 to 868951 | ORF Map | GBrowse

	View Computational GO annotations for RRS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP) ribosomal large subunit biogenesis (IMP) ribosomal large subunit export from nucleus (IMP)
Cellular Component
Manually curated	nuclear periphery (IDA) nucleolus (IDA) nucleoplasm (IDA) preribosome, large subunit precursor (IDA)
High-throughput	preribosome, large subunit precursor (IDA)

Classical genetics
conditional	cold sensitivity: increased nuclear morphology: abnormal 60S ribosomal subunit accumulation: decreased GFP-Rap1 distribution: abnormal silencing: decreased
null	inviable
Large-scale survey
null	inviable starvation resistance: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	128 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-MS: 64 Affinity Capture-Western: 13 Co-fractionation: 1 Co-localization: 1 Co-purification: 5 Far Western: 3 PCA: 2 Protein-RNA: 1 Reconstituted Complex: 2 Two-hybrid: 21
Genetic Interactions	Dosage Rescue: 1 Positive Genetic: 3 Synthetic Growth Defect: 1 Synthetic Lethality: 9 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:868340 to 868951 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..612 868340..868951 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005820