RRS1/YOR294W Summary Help

Standard Name RRS1 1
Systematic Name YOR294W
Feature Type ORF, Verified
Description Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice (1, 2, 3, 4, 5)
Name Description Regulator of Ribosome Synthesis 1
Chromosomal Location
ChrXV:868340 to 868951 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RRS1 GO evidence and references
  View Computational GO annotations for RRS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
reduction of function
repressible
Resources
138 total interaction(s) for 90 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 70
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 13
  • Co-fractionation: 1
  • Co-localization: 1
  • Co-purification: 5
  • Far Western: 3
  • PCA: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 24

Genetic Interactions
  • Dosage Rescue: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 9
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 203
Molecular Weight (Da) 22,963
Isoelectric Point (pI) 10.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:868340 to 868951 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..612 868340..868951 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005820
References cited on this page View Complete Literature Guide for RRS1
1) Tsuno A, et al.  (2000) RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Mol Cell Biol 20(6):2066-74
2) Morita D, et al.  (2002) Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. J Biol Chem 277(32):28780-6
3) Miyoshi K, et al.  (2004) Rrs1p, a ribosomal protein L11-binding protein, is required for nuclear export of the 60S pre-ribosomal subunit in Saccharomyces cerevisiae. FEBS Lett 565(1-3):106-10
4) Fossale E, et al.  (2002) Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice. Hum Mol Genet 11(19):2233-41
5) Horigome C, et al.  (2011) Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.LID - 10.1038/emboj.2011.267 [doi] EMBO J ()