Standard Name	YTM1 1
Systematic Name	YOR272W
Feature Type	ORF, Verified
Description	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats (2, 3, 4)

Chromosomal Location	ChrXV:832813 to 834195 | ORF Map | GBrowse

	View Computational GO annotations for YTM1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromosome organization (IGI) ribosomal large subunit biogenesis (IMP, IPI)
Cellular Component
Manually curated	nucleolus (IDA) PeBoW complex (IDA, IPI) preribosome, large subunit precursor (IDA)
High-throughput	nucleus (IDA) preribosome, large subunit precursor (IDA)

Classical genetics
conditional	27SA3 rRNA processing intermediate accumulation: increased growth in exponential phase: decreased heat sensitivity: increased 60S ribosomal subunit accumulation: decreased rpl25eGFP distribution: abnormal
Large-scale survey
null	inviable
overexpression	colony sectoring: increased vegetative growth: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	177 total interaction(s) for 74 unique genes/features.
Physical Interactions	Affinity Capture-MS: 144 Affinity Capture-Western: 20 Biochemical Activity: 1 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Positive Genetic: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:832813 to 834195 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1383 832813..834195 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005798