HRK1/YOR267C Summary Help

Standard Name HRK1 1
Systematic Name YOR267C
Feature Type ORF, Verified
Description Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress (1, 2)
Name Description Hygromycin Resistance Kinase 1
Chromosomal Location
ChrXV:824867 to 822588 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HRK1 GO evidence and references
  View Computational GO annotations for HRK1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
High-throughput
Regulators 11 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
141 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 58
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 15
  • Co-purification: 1
  • PCA: 1

Genetic Interactions
  • Dosage Growth Defect: 4
  • Negative Genetic: 45
  • Positive Genetic: 14

Resources
Expression Summary
histogram
Resources
Length (a.a.) 759
Molecular Weight (Da) 85,695
Isoelectric Point (pI) 7.28
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:824867 to 822588 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2280 824867..822588 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005793
References cited on this page View Complete Literature Guide for HRK1
1) Goossens A, et al.  (2000) Regulation of yeast H(+)-ATPase by protein kinases belonging to a family dedicated to activation of plasma membrane transporters. Mol Cell Biol 20(20):7654-61
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76