GPN2/YOR262W Summary Help

Standard Name GPN2 1
Systematic Name YOR262W
Feature Type ORF, Verified
Description Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion (2, 3, 4)
Name Description Gly-Pro-Asn (N) motif 1
Chromosomal Location
ChrXV:817292 to 818335 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GPN2 GO evidence and references
  View Computational GO annotations for GPN2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
Resources
20 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 2
  • Two-hybrid: 2

Genetic Interactions
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 347
Molecular Weight (Da) 39,724
Isoelectric Point (pI) 4.26
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:817292 to 818335 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1044 817292..818335 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005788
References cited on this page View Complete Literature Guide for GPN2
1) Alonso B, et al.  (2011) A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion. Cell Cycle 10(11):1828-37
2) Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65
3) Ben-Aroya S, et al.  (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58
4) Minaker SW, et al.  (2013) Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae. Genetics 193(3):853-64