RPN8/YOR261C Summary

RPN8 BASIC INFORMATION

Standard Name	RPN8 1
Systematic Name	YOR261C
Feature Type	ORF, Verified
Description	Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p (2)
Name Description	Regulatory Particle Non-ATPase 1

GO Annotations	All RPN8 GO evidence and references
	View Computational GO annotations for RPN8
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	proteasome regulatory particle, lid subcomplex (IDA, IPI) proteasome storage granule (IDA)

Mutant Phenotype	All RPN8 Phenotype details and references
Large-scale survey
null	inviable
repressible	mitochondrial morphology: abnormal

Interactions	RPN8 All interactions details and references
	207 total interaction(s) for 58 unique genes/features.
Physical Interactions	Affinity Capture-MS: 121 Affinity Capture-RNA: 1 Affinity Capture-Western: 23 Co-fractionation: 1 Co-purification: 2 PCA: 4 Two-hybrid: 7
Genetic Interactions	Dosage Rescue: 2 Phenotypic Suppression: 1 Synthetic Growth Defect: 26 Synthetic Rescue: 19

Sequence Information

ChrXV:816931 to 815915 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1017	816931..815915	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005787

RPN8 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RPN8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPN8]

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	Glickman MH, et al. (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62

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