Standard Name	RPT4 1, 2
Systematic Name	YOR259C
Alias	CRL13 , PCS1 , SUG2
Feature Type	ORF, Verified
Description	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization (3, 4, 5, 6, 7)
Name Description	Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1

Chromosomal Location	ChrXV:813708 to 812395 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 143 cM

	View Computational GO annotations for RPT4
Molecular Function
Manually curated	ATPase activity (ISS) protein domain specific binding (IDA)
Biological Process
Manually curated	ER-associated protein catabolic process (IMP) nucleotide-excision repair (IGI) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly (IMP) positive regulation of transcription elongation from RNA polymerase II promoter (IMP) proteasome regulatory particle assembly (IMP)
Cellular Component
Manually curated	nucleus (IDA) proteasome regulatory particle, base subcomplex (IDA)

Classical genetics
reduction of function	resistance to cadmium dichloride: decreased resistance to tunicamycin: increased
unspecified	Ub-Pro-beta-gal accumulation: increased
Large-scale survey
null	cell size: increased haploinsufficient inviable resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to clioquinol: decreased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	244 total interaction(s) for 146 unique genes/features.
Physical Interactions	Affinity Capture-MS: 90 Affinity Capture-RNA: 2 Affinity Capture-Western: 23 Co-fractionation: 2 Co-localization: 1 Co-purification: 5 PCA: 6 Reconstituted Complex: 5 Two-hybrid: 25
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 68 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 4 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:813708 to 812395 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 143 cM
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1314 813708..812395 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005785