Standard Name	CDC31
Systematic Name	YOR257W
Alias	DSK1
Feature Type	ORF, Verified
Description	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation (1, 2, 3)
Name Description	Cell Division Cycle 4

Chromosomal Location	ChrXV:811008 to 811493 | ORF Map | GBrowse
	Genetic position: 147 cM

	View Computational GO annotations for CDC31
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) proteasomal ubiquitin-dependent protein catabolic process (IMP, IPI) spindle pole body duplication associated with nuclear envelope (IMP)
Cellular Component
Manually curated	half bridge of spindle pole body (IDA) nuclear pore (TAS) colocalizes_with nucleotide-excision repair factor 2 complex (IPI) transcription export complex 2 (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	UV resistance: decreased cell cycle progression: arrested cell cycle progression through the G2/M phase transition: arrested cellular morphology: abnormal heat sensitivity: increased nuclear morphology: abnormal resistance to cycloheximide: decreased resistance to hygromycin B: decreased
overexpression	nuclear morphology: abnormal
Large-scale survey
conditional	resistance to benomyl: decreased
null	haploinsufficient inviable resistance to clioquinol: decreased
overexpression	cell cycle progression: abnormal vegetative growth: decreased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased
repressible	cytokinesis: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	114 total interaction(s) for 56 unique genes/features.
Physical Interactions	Affinity Capture-MS: 43 Affinity Capture-RNA: 1 Affinity Capture-Western: 23 Biochemical Activity: 3 Co-localization: 1 Co-purification: 1 Far Western: 1 Protein-peptide: 3 Reconstituted Complex: 10 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 12 Phenotypic Enhancement: 1 Synthetic Growth Defect: 6 Synthetic Lethality: 4 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:811008 to 811493 | ORF Map | GBrowse
	Genetic position: 147 cM
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..486 811008..811493 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005783