CDC31/YOR257W Summary Help

Standard Name CDC31 1
Systematic Name YOR257W
Alias DSK1
Feature Type ORF, Verified
Description Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation (2, 3, 4)
Name Description Cell Division Cycle 5
Chromosomal Location
ChrXV:811008 to 811493 | ORF Map | GBrowse
Gbrowse
Genetic position: 147 cM
Gene Ontology Annotations All CDC31 GO evidence and references
  View Computational GO annotations for CDC31
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
conditional
overexpression
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
Resources
114 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 43
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 23
  • Biochemical Activity: 3
  • Co-localization: 1
  • Co-purification: 1
  • Far Western: 1
  • Protein-peptide: 3
  • Reconstituted Complex: 10
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 12
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 4
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 161
Molecular Weight (Da) 18,751
Isoelectric Point (pI) 4.26
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:811008 to 811493 | ORF Map | GBrowse
SGD ORF map
Genetic position: 147 cM
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..486 811008..811493 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005783
References cited on this page View Complete Literature Guide for CDC31
1) Hartwell LH, et al.  (1973) Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. Genetics 74(2):267-286
2) Spang A, et al.  (1993) The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole body. J Cell Biol 123(2):405-16
3) Jaspersen SL, et al.  (2002) Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p. J Cell Biol 159(6):945-56
4) Chen L and Madura K  (2008) Centrin/Cdc31 is a novel regulator of protein degradation. Mol Cell Biol 28(5):1829-40
5) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9