APC5/YOR249C Summary

APC5 BASIC INFORMATION

Standard Name	APC5
Systematic Name	YOR249C
Alias	RMC1
Feature Type	ORF, Verified
Description	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition (1, 2)
Name Description	Anaphase Promoting Complex subunit

GO Annotations	All APC5 GO evidence and references
	View Computational GO annotations for APC5
Molecular Function
Manually curated	protein binding (TAS) ubiquitin-protein ligase activity (TAS)
Biological Process
Manually curated	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (IPI) chromatin assembly or disassembly (IMP) cyclin catabolic process (TAS) mitotic metaphase/anaphase transition (TAS) mitotic sister chromatid segregation (TAS) mitotic spindle elongation (TAS) protein ubiquitination (IPI)
Cellular Component
Manually curated	anaphase-promoting complex (IDA)

Mutant Phenotype	All APC5 Phenotype details and references
Large-scale survey
null	inviable

Interactions	APC5 All interactions details and references
	86 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 52 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Biochemical Activity: 2 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 7 Phenotypic Enhancement: 7 Phenotypic Suppression: 3 Synthetic Growth Defect: 2 Synthetic Lethality: 3 Synthetic Rescue: 1

Sequence Information

ChrXV:800732 to 798675 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2058	800732..798675	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005775

APC5 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for APC5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for APC5]

1)	Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9
2)	Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58

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