Standard Name	ESA1 1
Systematic Name	YOR244W
Alias	TAS1
Feature Type	ORF, Verified
Description	Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy (2, 3, 4, 5)
Gene Product Alias	KAT5 6

Chromosomal Location	ChrXV:792531 to 793868 | ORF Map | GBrowse

	View Computational GO annotations for ESA1
Molecular Function
Manually curated	H4 histone acetyltransferase activity (IDA) histone acetyltransferase activity (IMP) peptide N-acetyltransferase activity (IMP)
Biological Process
Manually curated	chromatin silencing at rDNA (IGI, IMP) DNA repair (IDA, IMP) DNA-dependent transcription, elongation (IDA, IMP) histone acetylation (IDA) peptidyl-lysine acetylation (IMP) positive regulation of macroautophagy (IMP) positive regulation of transcription elongation from RNA polymerase II promoter (IGI, IMP) regulation of cell cycle (IMP) regulation of transcription by chromatin organization (IMP) regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	NuA4 histone acetyltransferase complex (IPI) Piccolo NuA4 histone acetyltransferase complex (IDA)

Classical genetics
conditional	autophagy: decreased heat sensitivity: increased Nop1p distribution: abnormal Sir2p distribution: abnormal Nab3p distribution: abnormal histone H4 modification: decreased Atg3p modification: decreased Nab3p modification: decreased resistance to 6-azauracil: decreased resistance to camptothecin: decreased silencing: decreased
reduction of function	growth in exponential phase: decreased rate inviable histone H4 modification: decreased telomere length: decreased
unspecified	growth in exponential phase: normal rate
Large-scale survey
conditional	resistance to methyl methanesulfonate: decreased resistance to benomyl: decreased
null	haploinsufficient inviable starvation resistance: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	850 total interaction(s) for 560 unique genes/features.
Physical Interactions	Affinity Capture-MS: 73 Affinity Capture-RNA: 2 Affinity Capture-Western: 38 Biochemical Activity: 110 Co-crystal Structure: 1 Co-localization: 2 Co-purification: 13 Reconstituted Complex: 4 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 8 Negative Genetic: 66 Phenotypic Enhancement: 3 Phenotypic Suppression: 7 Positive Genetic: 6 Synthetic Growth Defect: 338 Synthetic Lethality: 162 Synthetic Rescue: 16
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:792531 to 793868 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1338 792531..793868 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005770