ESA1/YOR244W Summary Help

ESA1 BASIC INFORMATION

Standard Name ESA1 1
Systematic Name YOR244W
Alias TAS1
Feature Type ORF, Verified
Description Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus (2, 3, 4)
Gene Product Alias KAT5 5
GO Annotations All ESA1 GO evidence and references
    View Computational GO annotations for ESA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All ESA1 Phenotype details and references
Classical genetics
conditional
reduction of function
unspecified
Large-scale survey
null
Interactions ESA1 All interactions details and references
731 total interaction(s) for 490 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 72
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 29
  • Biochemical Activity: 98
  • Co-localization: 2
  • Co-purification: 13
  • Reconstituted Complex: 2
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 337
  • Synthetic Lethality: 154
  • Synthetic Rescue: 14
Sequence Information
ChrXV:792532 to 793869 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1338 792532..793869 2006-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005770

ESA1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for ESA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ESA1]

1) Clarke AS, et al.  (1999) Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol 19(4):2515-26
2) Allard S, et al.  (1999) NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J 18(18):5108-19
3) Smith ER, et al.  (1998) ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc Natl Acad Sci U S A 95(7):3561-5
4) Clarke AS, et al.  (2006) Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Mol Biol Cell 17(4):1744-57
5) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6