DFR1/YOR236W Summary Help

Standard Name DFR1 1
Systematic Name YOR236W
Feature Type ORF, Verified
Description Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism (2)
Name Description DihydroFolate Reductase 1
Chromosomal Location
ChrXV:780906 to 781541 | ORF Map | GBrowse
Gbrowse
Genetic position: 135 cM
Gene Ontology Annotations All DFR1 GO evidence and references
  View Computational GO annotations for DFR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
47 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2
  • Protein-peptide: 2
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 31
  • Positive Genetic: 4
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 211
Molecular Weight (Da) 24,261
Isoelectric Point (pI) 7.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:780906 to 781541 | ORF Map | GBrowse
SGD ORF map
Genetic position: 135 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..636 780906..781541 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005762
References cited on this page View Complete Literature Guide for DFR1
1) Lagosky PA, et al.  (1987) Molecular characterization of the Saccharomyces cerevisiae dihydrofolate reductase gene (DFR1). Nucleic Acids Res 15(24):10355-71
2) Huang T, et al.  (1992) The phenotype of a dihydrofolate reductase mutant of Saccharomyces cerevisiae. Gene 121(1):167-71