KIN4/YOR233W Summary Help

Standard Name KIN4 1
Systematic Name YOR233W
Alias KIN31 , KIN3 1
Feature Type ORF, Verified
Description Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description KINase 1, 6
Chromosomal Location
ChrXV:775846 to 778248 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All KIN4 GO evidence and references
  View Computational GO annotations for KIN4
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
Resources
266 total interaction(s) for 151 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Biochemical Activity: 21
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 37
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 123
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 4
  • Positive Genetic: 11
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 24

Resources
Expression Summary
histogram
Resources
Length (a.a.) 800
Molecular Weight (Da) 90,087
Isoelectric Point (pI) 10.3
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:775846 to 778248 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2403 775846..778248 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005759
References cited on this page View Complete Literature Guide for KIN4
1) Kambouris NG, et al.  (1993) Cloning and genetic analysis of the gene encoding a new protein kinase in Saccharomyces cerevisiae. Yeast 9(2):141-50
2) Zhu H, et al.  (2000) Analysis of yeast protein kinases using protein chips. Nat Genet 26(3):283-9
3) Pereira G and Schiebel E  (2005) Kin4 kinase delays mitotic exit in response to spindle alignment defects. Mol Cell 19(2):209-21
4) D'Aquino KE, et al.  (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 19(2):223-34
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Levin DE, et al.  (1987) Two yeast genes that encode unusual protein kinases. Proc Natl Acad Sci U S A 84(17):6035-9