WTM1/YOR230W Summary Help

Standard Name WTM1 1
Systematic Name YOR230W
Feature Type ORF, Verified
Description Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats (1, 2, 3)
Name Description WD repeat containing Transcriptional Modulator 1
Chromosomal Location
ChrXV:770800 to 772113 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All WTM1 GO evidence and references
  View Computational GO annotations for WTM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 37 genes
Regulators 15 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
58 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 9
  • Biochemical Activity: 1
  • Co-localization: 3
  • Co-purification: 3
  • PCA: 1
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 6
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 437
Molecular Weight (Da) 48,382
Isoelectric Point (pI) 5.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:770800 to 772113 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1314 770800..772113 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005756
References cited on this page View Complete Literature Guide for WTM1
1) Pemberton LF and Blobel G  (1997) Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Mol Cell Biol 17(8):4830-41
2) Zhang Z, et al.  (2006) Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proc Natl Acad Sci U S A 103(5):1422-7
3) Tringe SG, et al.  (2006) The WTM Genes in Budding Yeast Amplify Expression of the Stress-Inducible Gene RNR3. Genetics 174(3):1215-28