Standard Name	WTM1 1
Systematic Name	YOR230W
Feature Type	ORF, Verified
Description	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats (1, 2, 3)
Name Description	WD repeat containing Transcriptional Modulator 1

Chromosomal Location	ChrXV:770800 to 772113 | ORF Map | GBrowse

	View Computational GO annotations for WTM1
Molecular Function
Manually curated	protein binding (IPI) transcription corepressor activity (IDA)
Biological Process
Manually curated	maintenance of protein location in nucleus (IMP) negative regulation of chromatin silencing at silent mating-type cassette (IGI) negative regulation of chromatin silencing at telomere (IGI) negative regulation of transcription from RNA polymerase II promoter during meiosis (IGI) positive regulation of transcription from RNA polymerase II promoter (IDA, IGI, IMP) protein import into nucleus (IMP, IPI)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	nucleus (IDA)

Regulatory modules	predicted: cellcycle (275)
Resources	YeTFaSCo

Classical genetics
null	Rnr4p distribution: abnormal
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to amitrole: decreased resistance to acrolein: decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	52 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Biochemical Activity: 1 Co-localization: 3 Co-purification: 2 PCA: 1 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 6 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:770800 to 772113 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1314 770800..772113 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005756