WTM2/YOR229W Summary Help

Standard Name WTM2 1
Systematic Name YOR229W
Feature Type ORF, Verified
Description Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol in response to hypoxia; WTM2 has a paralog, UME1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description WD repeat containing Transcriptional Modulator 1
Chromosomal Location
ChrXV:768409 to 769812 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All WTM2 GO evidence and references
  View Computational GO annotations for WTM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 44 genes
Regulators 7 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
57 total interaction(s) for 42 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 5
  • Biochemical Activity: 1
  • Co-localization: 1
  • Co-purification: 2
  • PCA: 2
  • Two-hybrid: 13

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Negative Genetic: 11
  • Positive Genetic: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 467
Molecular Weight (Da) 51,951
Isoelectric Point (pI) 4.68
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:768409 to 769812 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1404 768409..769812 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005755
References cited on this page View Complete Literature Guide for WTM2
1) Pemberton LF and Blobel G  (1997) Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Mol Cell Biol 17(8):4830-41
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Tringe SG, et al.  (2006) The WTM Genes in Budding Yeast Amplify Expression of the Stress-Inducible Gene RNR3. Genetics 174(3):1215-28
4) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30