Standard Name	WTM2 1
Systematic Name	YOR229W
Feature Type	ORF, Verified
Description	Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; WTM2 has a paralog, UME1, that arose from the whole genome duplication (1, 2, 3)
Name Description	WD repeat containing Transcriptional Modulator 1

Chromosomal Location	ChrXV:768409 to 769812 | ORF Map | GBrowse

	View Computational GO annotations for WTM2
Molecular Function
Manually curated	protein binding (IPI) sequence-specific DNA binding RNA polymerase II transcription factor activity (IDA, IMP) transcription corepressor activity (IDA)
Biological Process
Manually curated	cellular protein complex localization (IMP) negative regulation of chromatin silencing at silent mating-type cassette (IGI) negative regulation of chromatin silencing at telomere (IGI) negative regulation of transcription from RNA polymerase II promoter during meiosis (IGI) positive regulation of transcription from RNA polymerase II promoter (IDA, IGI, IMP) response to DNA damage stimulus (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Regulatory modules	predicted: stressResponse (607) predicted: cellcycle (383, 347, 233) predicted: stressResponse (607) predicted: cellcycle (383, 347, 233)
Resources	YeTFaSCo

Classical genetics
null	RNR3-lacZ accumulation: decreased
overexpression	RNR3-lacZ accumulation: increased
Large-scale survey
null	competitive fitness: increased lifespan: increased starvation resistance: decreased viable
overexpression	inviable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	55 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 1 Co-localization: 1 Co-purification: 2 PCA: 2 Two-hybrid: 13
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 11 Positive Genetic: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:768409 to 769812 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1404 768409..769812 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005755