RFC1/YOR217W Summary

RFC1 BASIC INFORMATION

Standard Name	RFC1
Systematic Name	YOR217W
Alias	CDC44 1
Feature Type	ORF, Verified
Description	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon (2, 3)
Name Description	Replication Factor C 2

GO Annotations	All RFC1 GO evidence and references
	View Computational GO annotations for RFC1
Molecular Function
Manually curated	contributes_to DNA clamp loader activity (IDA)
Biological Process
Manually curated	DNA repair (IMP) leading strand elongation (IDA) mismatch repair (TAS) mitotic cell cycle (IMP)
Cellular Component
Manually curated	DNA replication factor C complex (IDA)

Mutant Phenotype	All RFC1 Phenotype details and references
Classical genetics
conditional	cell cycle progression: arrested cell cycle progression in S phase: increased duration cell cycle progression through the G2/M phase transition: arrested cellular morphology: abnormal cold sensitivity: increased
Large-scale survey
null	filamentous growth: increased inviable

Interactions	RFC1 All interactions details and references
	81 total interaction(s) for 49 unique genes/features.
Physical Interactions	Affinity Capture-MS: 30 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Co-purification: 4 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Phenotypic Enhancement: 22 Synthetic Growth Defect: 5 Synthetic Lethality: 7 Synthetic Rescue: 5

Sequence Information

ChrXV:749302 to 751887 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2586	749302..751887	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005743

RFC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RFC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RFC1]

1)	Moir D, et al. (1982) Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics 100(4):547-63
2)	Cullmann G, et al. (1995) Characterization of the five replication factor C genes of Saccharomyces cerevisiae. Mol Cell Biol 15(9):4661-71
3)	Yao N, et al. (2003) Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen. J Biol Chem 278(50):50744-53

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