SAS5/YOR213C Summary

SAS5 BASIC INFORMATION

Standard Name	SAS5
Systematic Name	YOR213C
Feature Type	ORF, Verified
Description	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity (1, 2)
Name Description	Something About Silencing

GO Annotations	All SAS5 GO evidence and references
	View Computational GO annotations for SAS5
Molecular Function
Manually curated	acetyltransferase activity (IDA) histone acetyltransferase activity (IDA)
Biological Process
Manually curated	chromatin silencing at telomere (IDA)
Cellular Component
Manually curated	nuclear chromatin (IDA) nuclear chromosome, telomeric region (IC) SAS acetyltransferase complex (IDA, IPI)

Mutant Phenotype	All SAS5 Phenotype details and references
Large-scale survey
null	viable
overexpression	silencing: abnormal

Interactions	SAS5 All interactions details and references
	56 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 9 Co-fractionation: 2 Reconstituted Complex: 4 Two-hybrid: 4
Genetic Interactions	Phenotypic Enhancement: 18 Phenotypic Suppression: 3 Synthetic Growth Defect: 5 Synthetic Lethality: 5 Synthetic Rescue: 1

Sequence Information

ChrXV:745282 to 744536 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..747	745282..744536	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005739

SAS5 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SAS5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAS5]

1)	Sutton A, et al. (2003) Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex. J Biol Chem 278(19):16887-92
2)	Shia WJ, et al. (2005) Characterization of the yeast trimeric-SAS acetyltransferase complex. J Biol Chem 280(12):11987-94

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