PTP2/YOR208W Summary Help

PTP2 BASIC INFORMATION

Standard Name PTP2
Systematic Name YOR208W
Feature Type ORF, Verified
Description Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus (1, 2, 3, 4)
Name Description Protein Tyrosine Phosphatase
GO Annotations All PTP2 GO evidence and references
    View Computational GO annotations for PTP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PTP2 Phenotype details and references
Large-scale survey
null
Interactions PTP2 All interactions details and references
53 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 7
  • Reconstituted Complex: 1
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 7
  • Phenotypic Enhancement: 12
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 5
  • Synthetic Rescue: 2
Sequence Information
ChrXV:733926 to 736178 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2253 733926..736178 2006-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005734

PTP2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PTP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PTP2]

1) Mattison CP, et al.  (1999) Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3. Mol Cell Biol 19(11):7651-60
2) Wurgler-Murphy SM, et al.  (1997) Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Mol Cell Biol 17(3):1289-97
3) Mattison CP and Ota IM  (2000) Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Genes Dev 14(10):1229-35
4) Winkler A, et al.  (2002) Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress. Eukaryot Cell 1(2):163-73