Standard Name	PTP2
Systematic Name	YOR208W
Feature Type	ORF, Verified
Description	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus (1, 2, 3, 4)
Name Description	Protein Tyrosine Phosphatase

Chromosomal Location	ChrXV:733925 to 736177 | ORF Map | GBrowse

	View Computational GO annotations for PTP2
Molecular Function
Manually curated	protein tyrosine phosphatase activity (IDA)
Biological Process
Manually curated	inactivation of MAPK activity involved in cell wall biogenesis (IGI, IMP) inactivation of MAPK activity involved in osmosensory signaling pathway (IGI) protein dephosphorylation (IMP) regulation of protein localization (IMP) regulation of sporulation (IGI)
Cellular Component
Manually curated	nucleus (IDA)

Classical genetics
null	resistance to OGT2468: decreased
Large-scale survey
null	competitive fitness: increased resistance to camptothecin: decreased resistance to tunicamycin: increased resistance to bleomycin: increased resistance to cycloheximide: increased resistance to caffeine: increased resistance to hydroxyurea: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	87 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 7 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 7 Negative Genetic: 16 Phenotypic Enhancement: 8 Phenotypic Suppression: 2 Positive Genetic: 5 Synthetic Growth Defect: 8 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 7 Synthetic Rescue: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:733925 to 736177 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2253 733925..736177 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005734