BFR1/YOR198C Summary Help

Standard Name BFR1 1
Systematic Name YOR198C
Feature Type ORF, Verified
Description Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity (1, 2)
Name Description BreFeldin A Resistance 1
Chromosomal Location
ChrXV:720065 to 718653 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All BFR1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 106 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
212 total interaction(s) for 130 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 9
  • Biochemical Activity: 3
  • PCA: 2
  • Protein-peptide: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 15

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 79
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 62
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 470
Molecular Weight (Da) 54,639
Isoelectric Point (pI) 9.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:720065 to 718653 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1413 720065..718653 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005724
References cited on this page View Complete Literature Guide for BFR1
1) Jackson CL and Kepes F  (1994) BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae. Genetics 137(2):423-37
2) Lang BD, et al.  (2001) The brefeldin A resistance protein Bfr1p is a component of polyribosome-associated mRNP complexes in yeast. Nucleic Acids Res 29(12):2567-74