BFR1/YOR198C Summary Help

Standard Name BFR1 1
Systematic Name YOR198C
Feature Type ORF, Verified
Description Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity (1, 2)
Name Description BreFeldin A Resistance 1
Chromosomal Location
ChrXV:720065 to 718653 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All BFR1 GO evidence and references
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
212 total interaction(s) for 130 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 9
  • Biochemical Activity: 3
  • PCA: 2
  • Protein-peptide: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 15

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 79
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 62
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 470
Molecular Weight (Da) 54,639
Isoelectric Point (pI) 9.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:720065 to 718653 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1413 720065..718653 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005724
References cited on this page View Complete Literature Guide for BFR1
1) Jackson CL and Kepes F  (1994) BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae. Genetics 137(2):423-37
2) Lang BD, et al.  (2001) The brefeldin A resistance protein Bfr1p is a component of polyribosome-associated mRNP complexes in yeast. Nucleic Acids Res 29(12):2567-74