Standard Name	MCA1 1
Systematic Name	YOR197W
Alias	YCA1 2
Feature Type	ORF, Verified
Description	Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization (2, 3, 4, 5) Also known as: [MCA] 6
Name Description	MetaCAspase 1

Chromosomal Location	ChrXV:717086 to 718384 | ORF Map | GBrowse

	View Computational GO annotations for MCA1
Molecular Function
Manually curated	calcium-dependent cysteine-type endopeptidase activity (IDA, IMP)
Biological Process
Manually curated	apoptotic process (IDA, IMP) misfolded or incompletely synthesized protein catabolic process (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Classical genetics
null	apoptosis: decreased cell cycle progression: abnormal cell cycle progression through the G1/S phase transition: delayed cell cycle progression through the G2/M phase transition: increased rate metal resistance: decreased nuclear morphology: abnormal 20S proteasome activity: increased insoluble protein accumulation: increased Rpt1p accumulation: decreased resistance to dihydromotuporamine C: decreased resistance to hypochlorous acid: decreased resistance to BAR0329: increased survival rate in stationary phase: decreased toxin resistance: increased vacuolar morphology: abnormal viability: increased
overexpression	apoptosis: increased
Large-scale survey
null	competitive fitness: decreased resistance to clioquinol: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	59 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 1 Biochemical Activity: 1 Reconstituted Complex: 1 Two-hybrid: 6
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 5 Phenotypic Enhancement: 1 Phenotypic Suppression: 6 Synthetic Growth Defect: 1 Synthetic Rescue: 11
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:717086 to 718384 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2006-05-11
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1299 717086..718384 2011-02-03 2006-05-11
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005723