SLK19/YOR195W Summary Help

SLK19 BASIC INFORMATION

Standard Name SLK19 1
Systematic Name YOR195W
Feature Type ORF, Verified
Description Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate (2, 3, 4)
Name Description Synthetic Lethal Kar3p 1
GO Annotations All SLK19 GO evidence and references
    View Computational GO annotations for SLK19
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SLK19 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions SLK19 All interactions details and references
106 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 3
  • PCA: 2
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 25
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 14
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 38
  • Synthetic Rescue: 3
Sequence Information
ChrXV:712867 to 715332 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2466 712867..715332 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005721

SLK19 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SLK19

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SLK19]

1) Zeng X, et al.  (1999) Slk19p is a centromere protein that functions to stabilize mitotic spindles. J Cell Biol 146(2):415-25
2) Stegmeier F, et al.  (2002) Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108(2):207-20
3) Pfiz S, et al.  (2002) The yeast kinetochore protein Slk19 is required to prevent aberrant chromosome segregation in meiosis and mitosis. Genes Cells 7(10):1033-42
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64