IES4/YOR189W Summary Help

Standard Name IES4 1
Systematic Name YOR189W
Feature Type ORF, Verified
Description Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses (1, 2)
Name Description Ino Eighty Subunit 1
Chromosomal Location
ChrXV:689624 to 689974 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IES4 GO evidence and references
  View Computational GO annotations for IES4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
activation
Large-scale survey
null
overexpression
Resources
156 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 2
  • Co-purification: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 97
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 10
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 116
Molecular Weight (Da) 13,092
Isoelectric Point (pI) 4.63
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:689624 to 689974 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..351 689624..689974 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005715
References cited on this page View Complete Literature Guide for IES4
1) Shen X, et al.  (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55
2) Morrison AJ, et al.  (2007) Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell 130(3):499-511