MSB1/YOR188W Summary Help

MSB1 BASIC INFORMATION

Standard Name MSB1
Systematic Name YOR188W
Feature Type ORF, Verified
Description Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4 (1, 2, 3 and see Summary Paragraph)
Name Description Multicopy Suppressor of a Budding defect
GO Annotations All MSB1 GO evidence and references
    View Computational GO annotations for MSB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All MSB1 Phenotype details and references
Large-scale survey
null
overexpression
Interactions MSB1 All interactions details and references
28 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 2
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 16
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2
Sequence Information
ChrXV:685768 to 689181 | ORF Map | GBrowse
Gbrowse
Genetic position: 103 cM
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3414 685768..689181 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005714

MSB1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MSB1

SUMMARY PARAGRAPH for MSB1

MSB1 was first identified as a high-copy suppressor of a temperature sensitive cdc24 mutation, and was also found to suppress mutations in cdc42 (1). Because of these genetic interactions with genes involved in the establishment of cell polarity and bud formation, Msb1p is thought to play a role in cell morphogenesis. Cells mutant for the genes BEM1 and BEM2, thought to be involved in bud emergence, require MSB1 for viability (4). A deletion of MSB1 does not produce a readily detectable phenotype (4).

Last updated: 1999-09-01

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MSB1]

1) Bender A and Pringle JR  (1989) Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc Natl Acad Sci U S A 86(24):9976-80
2) Sekiya-Kawasaki M, et al.  (2002) Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. Genetics 162(2):663-76
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Bender A and Pringle JR  (1991) Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. Mol Cell Biol 11(3):1295-305