Standard Name	SER1 1, 2
Systematic Name	YOR184W
Alias	ADE9 3
Feature Type	ORF, Verified
Description	3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress (3, 4, 5, 6)
Name Description	SERine requiring 7

Chromosomal Location	ChrXV:679357 to 680544 | ORF Map | GBrowse
	Genetic position: 98.2 cM

	View Computational GO annotations for SER1
Molecular Function
Manually curated	O-phospho-L-serine:2-oxoglutarate aminotransferase activity (IMP, ISS)
Biological Process
Manually curated	L-serine biosynthetic process (IMP, ISS) purine nucleobase biosynthetic process (IMP) serine family amino acid biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	serine biosynthesis from 3-phosphoglycerate superpathway of serine and glycine biosynthesis

Classical genetics
null	3-mercaptohexan-1-ol accumulation: decreased phospholipid accumulation: decreased Arn1p distribution: abnormal resistance to mycophenolic acid: decreased resistance to cobalt chloride hexahydrate: decreased
reduction of function	auxotrophy
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased fermentative growth: decreased rate resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to mycophenolic acid: decreased resistance to doxorubicin: decreased resistance to sirolimus: decreased resistance to leucascandrolide A analog 3: decreased resistance to edelfosine: decreased starvation resistance: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	118 total interaction(s) for 100 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Biochemical Activity: 1 Reconstituted Complex: 3 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 80 Positive Genetic: 7 Synthetic Growth Defect: 6 Synthetic Lethality: 7 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:679357 to 680544 | ORF Map | GBrowse
	Genetic position: 98.2 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1188 679357..680544 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005710