DCI1/YOR180C Summary Help

Standard Name DCI1
Systematic Name YOR180C
Alias ECI2
Feature Type ORF, Verified
Description Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication (1, 2, 3, 4, 5 and see Summary Paragraph)
Name Description delta(3,5)-delta(2,4)-Dienoyl-CoA Isomerase 3
Chromosomal Location
ChrXV:675167 to 674352 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All DCI1 GO evidence and references
  View Computational GO annotations for DCI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Pathways
Mutant phenotypes All DCI1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All DCI1 Interaction evidence and references
24 total interaction(s) for 21 unique genes/features.
Physical Interactions
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 12
  • Positive Genetic: 7
  • Synthetic Lethality: 1
Resources
Expression Summary
histogram
Resources
Protein Information All DCI1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:675167 to 674352 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..816 675167..674352 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005706
SUMMARY PARAGRAPH for DCI1

DCI1 encodes an enzyme involved in the beta-oxidation of fatty acids (3, 2). Dci1p is localized to the peroxisomal matrix (2) and has delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity (3). In the absence of the dodecenoyl-CoA delta-isomerase Eci1p, Dci1p is also associated with an enoyl-CoA isomerase activity that can replace Eci1p (3). Dci1p also interacts with Eci1p in the two-hybrid system (2). Geisbrect et al. (2) report that deletion of DCI1 causes a growth defect on oleic acid medium, but Gurvitz et al. (3) found no defect. An additional study (5) found no defect in growth of the null mutant on oleic acid, and also disputed the identification of Dci1p as a dienoyl-coA isomerase.

Last updated: 2009-05-14

References cited on this page View Complete Literature Guide for DCI1
1) Karpichev IV and Small GM  (2000) Evidence for a novel pathway for the targeting of a Saccharomyces cerevisiae peroxisomal protein belonging to the isomerase/hydratase family. J Cell Sci 113 ( Pt 3):533-44
2) Geisbrecht BV, et al.  (1999) Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism. Biochem Biophys Res Commun 260(1):28-34
3) Gurvitz A, et al.  (1999) Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1 encoding peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase. J Biol Chem 274(35):24514-21
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ntamack AG, et al.  (2009) Oleate beta-oxidation in yeast involves thioesterase but not Yor180c protein that is not a dienoyl-CoA isomerase. Biochim Biophys Acta 1791(5):371-8