Standard Name	ALE1 1
Systematic Name	YOR175C
Alias	SLC4 2 , LPT1 3 , LCA1 4
Feature Type	ORF, Verified
Description	Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids (1, 2, 3, 4, 5)
Name Description	Acyltransferase for Lyso-phosphatidylEthanolamine 1

Chromosomal Location	ChrXV:661674 to 659815 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ALE1
Molecular Function
Manually curated	1-acylglycerol-3-phosphate O-acyltransferase activity (IGI, IMP) 1-acylglycerophosphocholine O-acyltransferase activity (IMP) O-acyltransferase activity (IDA, IMP)
Biological Process
Manually curated	glycerophospholipid biosynthetic process (IGI, IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA)
High-throughput	endoplasmic reticulum (IDA) integral to membrane (ISM) colocalizes_with ribosome (IDA)

Classical genetics
null	membrane-bound O-acyltransferase activity: absent
Large-scale survey
null	competitive fitness: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	42 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 24 Phenotypic Enhancement: 2 Positive Genetic: 8 Synthetic Growth Defect: 2 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:661674 to 659815 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1860 661674..659815 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005701