DCS2/YOR173W Summary Help

DCS2 BASIC INFORMATION

Standard Name DCS2 1
Systematic Name YOR173W
Feature Type ORF, Verified
Description Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p. (2, 3, 4, 5)
Name Description DeCapping Scavenger 1, 3
GO Annotations All DCS2 GO evidence and references
    View Computational GO annotations for DCS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All DCS2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions DCS2 All interactions details and references
9 total interaction(s) for 7 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
Sequence Information
ChrXV:657265 to 658326 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-10-05 | Sequence: 2006-10-05
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1062 657265..658326 2006-10-05 2006-10-05
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005699

DCS2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for DCS2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DCS2]

1) Kwasnicka DA, et al.  (2003) Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. J Biol Chem 278(40):39051-8
2) Tadi D, et al.  (1999) Selection of genes repressed by cAMP that are induced by nutritional limitation in Saccharomyces cerevisiae. Yeast 15(16):1733-45
3) Liu H, et al.  (2002) The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. EMBO J 21(17):4699-708
4) Malys N, et al.  (2004) The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast. Nucleic Acids Res 32(12):3590-600
5) Malys N and McCarthy JE  (2006) Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies. J Mol Biol 363(2):370-82