Standard Name	SEY1 1
Systematic Name	YOR165W
Feature Type	ORF, Verified
Description	Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 (1, 2, 3)
Name Description	Synthetic Enhancement of YOP1 1

Chromosomal Location	ChrXV:644566 to 646896 | ORF Map | GBrowse

	View Computational GO annotations for SEY1
Molecular Function
Manually curated	GTPase activity (IMP)
Biological Process
Manually curated	cellular membrane organization (IGI) endoplasmic reticulum inheritance (IGI) endoplasmic reticulum membrane fusion (IDA, IGI, IMP) endoplasmic reticulum organization (IGI)
Cellular Component
Manually curated	cortical endoplasmic reticulum (IDA) endoplasmic reticulum (IDA)
High-throughput	cytoplasm (IDA) integral to membrane (ISM)

Classical genetics
null	endoplasmic reticulum morphology: abnormal nuclear fusion during mating: decreased
Large-scale survey
null	competitive fitness: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	101 total interaction(s) for 54 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 PCA: 9
Genetic Interactions	Negative Genetic: 50 Phenotypic Enhancement: 11 Phenotypic Suppression: 5 Positive Genetic: 12 Synthetic Growth Defect: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:644566 to 646896 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2331 644566..646896 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005691