SEY1/YOR165W Summary Help

Standard Name SEY1 1
Systematic Name YOR165W
Feature Type ORF, Verified
Description Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 (1, 2, 3)
Name Description Synthetic Enhancement of YOP1 1
Chromosomal Location
ChrXV:644566 to 646896 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SEY1 GO evidence and references
  View Computational GO annotations for SEY1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
111 total interaction(s) for 58 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Co-purification: 1
  • PCA: 9

Genetic Interactions
  • Negative Genetic: 57
  • Phenotypic Enhancement: 11
  • Phenotypic Suppression: 5
  • Positive Genetic: 13
  • Synthetic Growth Defect: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 776
Molecular Weight (Da) 89,432
Isoelectric Point (pI) 5.03
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:644566 to 646896 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2331 644566..646896 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005691
References cited on this page View Complete Literature Guide for SEY1
1) Brands A and Ho TH  (2002) Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic. Plant Physiol 130(3):1121-31
2) Hu J, et al.  (2009) A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell 138(3):549-61
3) Anwar K, et al.  (2012) The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol 197(2):209-17