YRR1/YOR162C Summary

Standard Name	YRR1 1
Systematic Name	YOR162C
Alias	PDR2 2 , 3
Feature Type	ORF, Verified
Description	Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication (1, 4, 5, 6, 7)
Name Description	Yeast Reveromycin-A Resistant 1

Chromosomal Location	ChrXV:641992 to 639560 \| ORF Map \| GBrowse
	Note: this feature is encoded on the Crick strand.

	Genetic position: 89 cM

	View Computational GO annotations for YRR1
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) sequence-specific DNA binding RNA polymerase II transcription factor activity (IDA, IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IDA) regulation of transcription from RNA polymerase II promoter in response to oxidative stress (IDA, IGI, IMP)
Cellular Component
Manually curated	nucleus (IC)

Regulatory Role

Binding motifs	RCGGAAATAA 8 [Search intergenic regions for RCGGAAATAA] RCGGRDWTWD 9 [Search intergenic regions for RCGGRDWTWD]

Regulatory modules	predicted: stressResponse (577)

Resources	ScerTF \| UniProbe \| YEASTRACT \| YeTFaSCo

Classical genetics
null	resistance to mancozeb: decreased resistance to Calcofluor White: decreased respiratory metabolism: decreased viable
Large-scale survey
null	competitive fitness: increased resistance to 4-nitroquinoline N-oxide: decreased resistance to cycloheximide: decreased resistance to ketoconazole: normal resistance to chloramphenicol: normal resistance to rhodamine 6-G: normal resistance to oligomycin: normal vacuolar morphology: abnormal viable
overexpression	resistance to LY-83583: increased vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

	26 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 1 Biochemical Activity: 6 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 2 Negative Genetic: 5 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 3
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder \| YeastRC Two-Hybrid

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Localization	YeastRC \| Organelle DB (UMich) \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXV:641992 to 639560 | |

Note: this feature is encoded on the Crick strand.

: 89 cM

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2433	641992..639560	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000005688

1)	Cui Z, et al. (1998) Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Mol Microbiol 29(5):1307-15
2)	Golin, J. (1989) Personal Communication, Mortimer Map Edition 10
3)	Keeven J, et al. (2002) PDR2 Gain-of-function mutations eliminate the need for Pdr1 and require the UBP6 product for resistance to translational inhibitors. Curr Genet 41(1):11-9
4)	Zhang X, et al. (2001) Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. J Biol Chem 276(12):8812-9
5)	Le Crom S, et al. (2002) New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol Cell Biol 22(8):2642-9
6)	Lucau-Danila A, et al. (2003) Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. J Biol Chem 278(52):52641-50
7)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8)	Zhu C, et al. (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
9)	Badis G, et al. (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87