Standard Name	MTR10
Systematic Name	YOR160W
Alias	KAP111
Feature Type	ORF, Verified
Description	Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	Mrna TRansport defective 6

Chromosomal Location	ChrXV:633839 to 636757 | ORF Map | GBrowse

	View Computational GO annotations for MTR10
Molecular Function
Manually curated	nuclear localization sequence binding (IPI)
Biological Process
Manually curated	mRNA-binding (hnRNP) protein import into nucleus (IMP, IPI, ISS) protein import into nucleus (IMP, IPI, ISS) RNA import into nucleus (IMP) RNA localization (IMP) tRNA transport (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA) integral to membrane (ISM) nuclear periphery (IDA)

Classical genetics
conditional	poly(A)+ RNA accumulation: increased nuclear import: decreased
null	telomere length: decreased
reduction of function	resistance to benomyl: decreased
Large-scale survey
conditional	colony sectoring: increased heat sensitivity: increased
null	inviable telomere length: decreased
reduction of function	competitive fitness: decreased resistance to benomyl: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	40 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Far Western: 1 Reconstituted Complex: 4 Two-hybrid: 11
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Phenotypic Suppression: 1 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:633839 to 636757 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2919 633839..636757 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005686