MTR10/YOR160W Summary

MTR10 BASIC INFORMATION

Standard Name	MTR10
Systematic Name	YOR160W
Alias	KAP111
Feature Type	ORF, Verified
Description	Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs (1, 2, 3, 4)
Name Description	Mrna TRansport defective 5

GO Annotations	All MTR10 GO evidence and references
	View Computational GO annotations for MTR10
Molecular Function
Manually curated	nuclear localization sequence binding (IPI)
Biological Process
Manually curated	mRNA-binding (hnRNP) protein import into nucleus (IMP, IPI, ISS) protein import into nucleus (IMP, IPI, ISS) RNA import into nucleus (IMP) RNA localization (IMP) tRNA transport (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All MTR10 Phenotype details and references
Classical genetics
conditional	poly(A)+ RNA accumulation: increased nuclear import: decreased
null	telomere length: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable

Interactions	MTR10 All interactions details and references
	36 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Far Western: 1 Reconstituted Complex: 3 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 1 Synthetic Lethality: 4 Synthetic Rescue: 1

Sequence Information

ChrXV:633840 to 636758 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2919	633840..636758	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005686

MTR10 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MTR10

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MTR10]

1)	Pemberton LF, et al. (1997) A distinct and parallel pathway for the nuclear import of an mRNA-binding protein. J Cell Biol 139(7):1645-53
2)	Senger B, et al. (1998) Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. EMBO J 17(8):2196-207
3)	Windgassen M, et al. (2004) Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor. Mol Cell Biol 24(23):10479-91
4)	Murthi A, et al. (2009) Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in S. cerevisiae. Mol Biol Cell ()
5)	Kadowaki T, et al. (1994) Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants. J Cell Biol 126(3):649-59

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