RUP1/YOR138C Summary

RUP1 BASIC INFORMATION

Standard Name	RUP1
Systematic Name	YOR138C
Feature Type	ORF, Verified
Description	Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain (1, 2)
Name Description	Rsp5-Ubp2 interacting Protein 2

GO Annotations	All RUP1 GO evidence and references
	View Computational GO annotations for RUP1
Molecular Function
Manually curated	protein binding (IDA)
Biological Process
Manually curated	protein deubiquitination (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All RUP1 Phenotype details and references
Large-scale survey
null	viable

Interactions	RUP1 All interactions details and references
	27 total interaction(s) for 10 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-Western: 7 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 3 Phenotypic Suppression: 1

Sequence Information

ChrXV:586325 to 584310 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2016	586325..584310	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005664

RUP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RUP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RUP1]

1)	Kee Y, et al. (2005) The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme. EMBO J 24(13):2414-24
2)	Lam MH, et al. (2009) Interaction of the Deubiquitinating Enzyme Ubp2 and the E3 Ligase Rsp5 Is Required for Transporter/Receptor Sorting in the Multivesicular Body Pathway. PLoS ONE 4(1):e4259

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