Standard Name	IDH2
Systematic Name	YOR136W
Feature Type	ORF, Verified
Description	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated (1, 2)
Name Description	Isocitrate DeHydrogenase

Chromosomal Location	ChrXV:580250 to 581359 | ORF Map | GBrowse

	View Computational GO annotations for IDH2
Molecular Function
Manually curated	contributes_to isocitrate dehydrogenase (NAD+) activity (IDA)
Biological Process
Manually curated	glutamate biosynthetic process (TAS) isocitrate metabolic process (TAS) tricarboxylic acid cycle (TAS)
Cellular Component
Manually curated	mitochondrial isocitrate dehydrogenase complex (NAD+) (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Classical genetics
null	2-oxoglutarate(2-) accumulation: decreased tellurium atom accumulation: decreased isocitrate(3-) accumulation: increased heat sensitivity: decreased nutrient utilization: decreased oxidative stress resistance: increased replicative lifespan: increased resistance to sirolimus: increased respiratory growth: decreased rate utilization of carbon source: absent
reduction of function	mitochondrial genome maintenance: decreased respiratory growth: decreased rate utilization of carbon source: absent vegetative growth: decreased rate
unspecified	utilization of carbon source: absent
Large-scale survey
null	cell cycle progression in G1 phase: increased duration glycogen accumulation: decreased competitive fitness: decreased competitive fitness: increased heat sensitivity: increased hyperosmotic stress resistance: decreased replicative lifespan: increased resistance to sirolimus: increased resistance to wortmannin: decreased resistance to monensin: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate sporulation efficiency: decreased stress resistance: increased toxin resistance: decreased utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	247 total interaction(s) for 169 unique genes/features.
Physical Interactions	Affinity Capture-MS: 43 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-crystal Structure: 2 Co-purification: 1 PCA: 1 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 123 Phenotypic Enhancement: 3 Phenotypic Suppression: 10 Positive Genetic: 46 Synthetic Growth Defect: 5 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:580250 to 581359 | ORF Map | GBrowse
	This feature is contained within: 70626
	This feature is contained within: 70237
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1110 580250..581359 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005662