IDH2/YOR136W Summary Help

Standard Name IDH2 1
Systematic Name YOR136W
Feature Type ORF, Verified
Description Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated (1, 2)
Name Description Isocitrate DeHydrogenase 1
Chromosomal Location
ChrXV:580250 to 581359 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IDH2 GO evidence and references
  View Computational GO annotations for IDH2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 12 genes
Resources
Pathways
Classical genetics
null
reduction of function
unspecified
Large-scale survey
null
overexpression
Resources
251 total interaction(s) for 171 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 46
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Co-crystal Structure: 2
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 123
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 10
  • Positive Genetic: 46
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 369
Molecular Weight (Da) 39,739
Isoelectric Point (pI) 9.15
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:580250 to 581359 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1110 580250..581359 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005662
References cited on this page View Complete Literature Guide for IDH2
1) Cupp JR and McAlister-Henn L  (1991) NAD(+)-dependent isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae. J Biol Chem 266(33):22199-205
2) Reinders J, et al.  (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906