VPS17/YOR132W Summary Help

VPS17 BASIC INFORMATION

Standard Name VPS17 1, 2
Systematic Name YOR132W
Alias PEP21 , VPT3 3
Feature Type ORF, Verified
Description Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation (4, 5, 6)
Name Description Vacuolar Protein Sorting 1, 2
GO Annotations All VPS17 GO evidence and references
    View Computational GO annotations for VPS17
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All VPS17 Phenotype details and references
Classical genetics
reduction of function
Large-scale survey
null
Interactions VPS17 All interactions details and references
61 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 10
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 5
  • Reconstituted Complex: 5
  • Two-hybrid: 9
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 10
Sequence Information
ChrXV:573176 to 574831 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1656 573176..574831 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005658

VPS17 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for VPS17

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VPS17]

1) Robinson JS, et al.  (1988) Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 8(11):4936-48
2) Rothman JH, et al.  (1989) Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae. EMBO J 8(7):2057-65
3) Bankaitis VA, et al.  (1986) Isolation of yeast mutants defective in protein targeting to the vacuole. Proc Natl Acad Sci U S A 83(23):9075-9
4) Seaman MN, et al.  (1998) A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142(3):665-81
5) Kohrer K and Emr SD  (1993) The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. J Biol Chem 268(1):559-69
6) Horazdovsky BF, et al.  (1997) A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Mol Biol Cell 8(8):1529-41