ORT1/YOR130C Summary Help

Standard Name ORT1 1
Systematic Name YOR130C
Alias ARG11
Feature Type ORF, Verified
Description Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome (2, 3 and see Summary Paragraph)
Name Description ORnithine Transporter 1
Chromosomal Location
ChrXV:570807 to 569929 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ORT1 GO evidence and references
  View Computational GO annotations for ORT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
20 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 4
  • PCA: 1

Genetic Interactions
  • Positive Genetic: 10
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 292
Molecular Weight (Da) 31,520
Isoelectric Point (pI) 9.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:570807 to 569929 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..879 570807..569929 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005656
SUMMARY PARAGRAPH for ORT1

ORT1 encodes an ornithine transporter localized to the mitochondrial inner membrane (2, 3). In yeast, ornithine is synthesized in the mitochondrial matrix and transported to the cytosol, where it is converted to arginine (4). Mutations in ORT1 cause slow growth in the absence of arginine (2); the residual growth may be due to Bac1p, another mitochondrial inner membrane transporter (5). Mutations in ORNT1, a human gene orthologous to ORT1, are associated with hyperammonemia-hyperornithinemia-homocitrullinuria (HHH) syndrome (OMIM) (6).

Last updated: 2005-07-01 Contact SGD

References cited on this page View Complete Literature Guide for ORT1
1) Palmieri L, et al.  (2000) Identification and functions of new transporters in yeast mitochondria. Biochim Biophys Acta 1459(2-3):363-9
2) Crabeel M, et al.  (1996) The ARG11 gene of Saccharomyces cerevisiae encodes a mitochondrial integral membrane protein required for arginine biosynthesis. J Biol Chem 271(40):25011-8
3) Palmieri L, et al.  (1997) Identification of the yeast ARG-11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis. FEBS Lett 410(2-3):447-51
4) Jauniaux JC, et al.  (1978) Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes. J Bacteriol 133(3):1096-1107
5) Soetens O, et al.  (1998) Transport of arginine and ornithine into isolated mitochondria of Saccharomyces cerevisiae. Eur J Biochem 258(2):702-9
6) Camacho JA, et al.  (1999) Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. Nat Genet 22(2):151-8