RGA1/YOR127W Summary

RGA1 BASIC INFORMATION

Standard Name	RGA1
Systematic Name	YOR127W
Alias	DBM1 1 , THE1
Feature Type	ORF, Verified
Description	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth (2, 3)
Name Description	Rho GTPase Activating Protein 2

GO Annotations	All RGA1 GO evidence and references
	View Computational GO annotations for RGA1
Molecular Function
Manually curated	Rho GTPase activator activity (IDA, IGI, IPI)
Biological Process
Manually curated	actin filament organization (IMP) budding cell apical bud growth (IPI) budding cell isotropic bud growth (IPI) establishment of cell polarity (IMP) invasive growth in response to glucose limitation (IPI) pheromone-dependent signal transduction involved in conjugation with cellular fusion (IGI) pseudohyphal growth (IPI) small GTPase mediated signal transduction (TAS)
Cellular Component
Manually curated	cellular bud neck split septin rings (IDA)

Mutant Phenotype	All RGA1 Phenotype details and references
Classical genetics
null	axial budding pattern: decreased budding: abnormal cellular morphology: abnormal invasive growth: increased Kss1p modification: increased resistance to tunicamycin: normal resistance to L-1,4-dithiothreitol: normal resistance to mercaptoethanol: decreased
Large-scale survey
null	bud morphology: abnormal resistance to ethanol: decreased respiratory growth: absent viable

Interactions	RGA1 All interactions details and references
	50 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 3 PCA: 1 Reconstituted Complex: 1 Two-hybrid: 15
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 7 Synthetic Rescue: 2

Sequence Information

ChrXV:561171 to 564194 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3024	561171..564194	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005653

RGA1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RGA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RGA1]

1)	Chen GC, et al. (1996) The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae. Mol Cell Biol 16(4):1376-90
2)	Stevenson BJ, et al. (1995) Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes Dev 9(23):2949-63
3)	Smith GR, et al. (2002) GTPase-activating proteins for Cdc42. Eukaryot Cell 1(3):469-80

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.