CEX1/YOR112W Summary Help

Standard Name CEX1 1
Systematic Name YOR112W
Feature Type ORF, Verified
Description Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex (1, 2)
Name Description Cytoplasmic EXport protein 1
Chromosomal Location
ChrXV:531508 to 533793 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CEX1 GO evidence and references
  View Computational GO annotations for CEX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Large-scale survey
null
overexpression
Resources
52 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 10
  • Co-purification: 1
  • Protein-RNA: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 14
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 761
Molecular Weight (Da) 84,768
Isoelectric Point (pI) 5.13
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:531508 to 533793 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2286 531508..533793 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005638
References cited on this page View Complete Literature Guide for CEX1
1) McGuire AT and Mangroo D  (2007) Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery. EMBO J 26(2):288-300
2) McGuire AT and Mangroo D  (2012) Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex. Traffic 13(2):234-56