KTR1/YOR099W Summary Help

Standard Name KTR1 1
Systematic Name YOR099W
Feature Type ORF, Verified
Description Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress (2, 3, 4)
Name Description Kre Two Related 2
Chromosomal Location
ChrXV:511825 to 513006 | ORF Map | GBrowse
Gbrowse
Genetic position: 54 cM
Gene Ontology Annotations All KTR1 GO evidence and references
  View Computational GO annotations for KTR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Large-scale survey
null
overexpression
Resources
33 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-purification: 2
  • PCA: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 11
  • Phenotypic Enhancement: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 393
Molecular Weight (Da) 46,022
Isoelectric Point (pI) 6.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:511825 to 513006 | ORF Map | GBrowse
SGD ORF map
Genetic position: 54 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1182 511825..513006 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005625
References cited on this page View Complete Literature Guide for KTR1
1) Hill K, et al.  (1992) Yeast KRE2 defines a new gene family encoding probable secretory proteins, and is required for the correct N-glycosylation of proteins. Genetics 130(2):273-83
2) Lussier M, et al.  (1997) Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Yeast 13(3):267-74
3) Lussier M, et al.  (1997) The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. J Biol Chem 272(24):15527-31
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76