VPS21/YOR089C Summary Help

VPS21 BASIC INFORMATION

Standard Name VPS21 1, 2
Systematic Name YOR089C
Alias VPS12 1 , 2 , 3 , VPT12 1 , YPT21 , YPT51
Feature Type ORF, Verified
Description GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog (4, 5, 6, 7)
Name Description Vacuolar Protein Sorting 1, 2
GO Annotations All VPS21 GO evidence and references
    View Computational GO annotations for VPS21
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All VPS21 Phenotype details and references
Classical genetics
reduction of function
Large-scale survey
null
Interactions VPS21 All interactions details and references
193 total interaction(s) for 130 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 5
  • PCA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 11
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 104
  • Phenotypic Suppression: 8
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 23
  • Synthetic Rescue: 2
Sequence Information
ChrXV:490830 to 490198 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..633 490830..490198 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005615

VPS21 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for VPS21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VPS21]

1) Robinson JS, et al.  (1988) Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 8(11):4936-48
2) Rothman JH, et al.  (1989) Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae. EMBO J 8(7):2057-65
3) Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402
4) Horazdovsky BF, et al.  (1994) VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins. EMBO J 13(6):1297-309
5) Singer-Kruger B, et al.  (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J Cell Biol 125(2):283-98
6) Neukamm B, et al.  (2002) Endocytosis is involved in DNA uptake in yeast. Biochim Biophys Acta 1572(1):67-76
7) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12