LPX1/YOR084W Summary Help

Standard Name LPX1 1
Systematic Name YOR084W
Feature Type ORF, Verified
Description Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible (1, 2, 3, 4)
Name Description Lipase of PeroXisomes 1
Chromosomal Location
ChrXV:480587 to 481750 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LPX1 GO evidence and references
  View Computational GO annotations for LPX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
unspecified
Resources
17 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Co-crystal Structure: 1
  • Co-purification: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 6
  • Positive Genetic: 2
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 387
Molecular Weight (Da) 43,727
Isoelectric Point (pI) 8.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:480587 to 481750 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1164 480587..481750 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005610
References cited on this page View Complete Literature Guide for LPX1
1) Thoms S, et al.  (2008) Lpx1p is a peroxisomal lipase required for normal peroxisome morphology. FEBS J 275(3):504-14
2) Smith JJ, et al.  (2002) Transcriptome profiling to identify genes involved in peroxisome assembly and function. J Cell Biol 158(2):259-71
3) Lucau-Danila A, et al.  (2003) Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. J Biol Chem 278(52):52641-50
4) Ploier B, et al.  (2013) Screening for Hydrolytic Enzymes Reveals Ayr1p as a Novel Triacylglycerol Lipase in Saccharomyces cerevisiae. J Biol Chem 288(50):36061-72