Standard Name	CDC21
Systematic Name	YOR074C
Alias	CRT9 , TMP1 1
Feature Type	ORF, Verified
Description	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S (1, 2) Also known as: YOR29-25
Name Description	Cell Division Cycle 3

Chromosomal Location	ChrXV:467589 to 466675 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 32 cM

	View Computational GO annotations for CDC21
Molecular Function
Manually curated	thymidylate synthase activity (IDA)
Biological Process
Manually curated	dTMP biosynthetic process (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Pathways	de novo biosynthesis of pyrimidine deoxyribonucleotides

Classical genetics
conditional	cell cycle progression: arrested cell cycle progression in S phase: delayed cellular morphology: abnormal growth in exponential phase: decreased rate heat sensitivity: increased petite
null	resistance to 5-fluorouracil: decreased
reduction of function	resistance to 5-fluorouracil: decreased
Large-scale survey
null	haploproficient inviable
reduction of function	competitive fitness: decreased
repressible	cell cycle progression in S phase: abnormal chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	17 total interaction(s) for 14 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 3
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 1 Phenotypic Enhancement: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:467589 to 466675 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 32 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..915 467589..466675 2011-02-03 2005-12-01
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005600