SGO1/YOR073W Summary Help

Standard Name SGO1 1
Systematic Name YOR073W
Alias YOR29-24
Feature Type ORF, Verified
Description Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension (1, 2, 3, 4)
Name Description ShuGOshin (Japanese for "guardian spirit") 1
Chromosomal Location
ChrXV:464771 to 466543 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SGO1 GO evidence and references
  View Computational GO annotations for SGO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
124 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • PCA: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Rescue: 7
  • Negative Genetic: 39
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 8
  • Positive Genetic: 18
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 12
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 590
Molecular Weight (Da) 66,706
Isoelectric Point (pI) 10.05
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:464771 to 466543 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1773 464771..466543 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005599
References cited on this page View Complete Literature Guide for SGO1
1) Kitajima TS, et al.  (2004) The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature 427(6974):510-7
2) Indjeian VB, et al.  (2005) The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes. Science 307(5706):130-3
3) Nerusheva OO, et al.  (2014) Tension-dependent removal of pericentromeric shugoshin is an indicator of sister chromosome biorientation. Genes Dev 28(12):1291-309
4) Peplowska K, et al.  (2014) Sgo1 regulates both condensin and ipl1/aurora B to promote chromosome biorientation. PLoS Genet 10(6):e1004411