YNG1/YOR064C Summary Help

Standard Name YNG1
Systematic Name YOR064C
Alias YOR29-15
Feature Type ORF, Verified
Description Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 (1, 2, 3, 4)
Name Description Yeast homolog of mammalian Ing1
Chromosomal Location
ChrXV:446738 to 446079 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All YNG1 GO evidence and references
  View Computational GO annotations for YNG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
79 total interaction(s) for 54 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 5
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 7
  • Co-localization: 1
  • Co-purification: 1
  • Protein-peptide: 6
  • Reconstituted Complex: 2

Genetic Interactions
  • Negative Genetic: 9
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 2
  • Synthetic Rescue: 20

Resources
Expression Summary
histogram
Resources
Length (a.a.) 219
Molecular Weight (Da) 25,350
Isoelectric Point (pI) 8.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:446738 to 446079 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..660 446738..446079 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005590
References cited on this page View Complete Literature Guide for YNG1
1) Loewith R, et al.  (2000) Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol 20(11):3807-16
2) Howe L, et al.  (2002) Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 Hhistone acetyltransferase complex. Mol Cell Biol 22(14):5047-53
3) Martin DG, et al.  (2006) The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol 26(21):7871-9
4) Taverna SD, et al.  (2006) Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 24(5):785-96