Standard Name	ASE1
Systematic Name	YOR058C
Alias	YOR29-09
Feature Type	ORF, Verified
Description	Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress (1, 2, 3, 4)
Name Description	Anaphase Spindle Elongation 5

Chromosomal Location	ChrXV:436345 to 433688 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ASE1
Molecular Function
Manually curated	microtubule binding (IDA)
Biological Process
Manually curated	cytokinesis, completion of separation (IMP) microtubule bundle formation (IDA) mitotic anaphase B (IMP) mitotic spindle elongation (IGI, IMP) mitotic spindle stabilization (IMP) spindle midzone assembly (IMP) spindle pole body separation (IGI)
Cellular Component
Manually curated	nuclear microtubule (IDA) spindle (IDA) spindle midzone (IDA)
High-throughput	cytoplasm (IDA) microtubule (IDA)

Classical genetics
conditional	spindle morphology: abnormal
misexpression	cell cycle progression: delayed
null	chromosome/plasmid maintenance: abnormal cytokinesis: abnormal spindle morphology: abnormal toxin resistance: increased
overexpression	cell cycle passage through the metaphase-anaphase transition: delayed spindle morphology: abnormal
Large-scale survey
null	competitive fitness: decreased resistance to fenpropimorph: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to sirolimus: decreased resistance to hydroxyurea: decreased resistance to fluconazole: decreased resistance to caffeine: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	243 total interaction(s) for 128 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 1 Biochemical Activity: 2 Protein-RNA: 1 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 115 Phenotypic Enhancement: 1 Phenotypic Suppression: 8 Positive Genetic: 12 Synthetic Growth Defect: 30 Synthetic Lethality: 47 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:436345 to 433688 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2658 436345..433688 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005584