Standard Name	SGT1 1
Systematic Name	YOR057W
Feature Type	ORF, Verified
Description	Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress (1, 2, 3, 4) Also known as: YOR29-08
Name Description	Suppressor of G2 (Two) allele of skp1 1

Chromosomal Location	ChrXV:432186 to 433373 | ORF Map | GBrowse

	View Computational GO annotations for SGT1
Molecular Function
Manually curated	chaperone binding (IDA, ISS) protein binding, bridging (IDA)
Biological Process
Manually curated	cAMP-mediated signaling (IGI, IPI) kinetochore assembly (IDA) protein complex assembly (IDA, IGI, ISS) protein ubiquitination (TAS) regulation of cell cycle (TAS)
Cellular Component
Manually curated	ubiquitin ligase complex (IDA)

Classical genetics
conditional	cell cycle progression in G1 phase: arrested cell cycle progression through the G2/M phase transition: arrested chromosome segregation: abnormal heat sensitivity: increased nuclear position: abnormal Sic1p accumulation: increased
null	inviable
reduction of function	resistance to benomyl: decreased
Large-scale survey
conditional	colony sectoring: increased
null	inviable
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	70 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 17 Biochemical Activity: 1 PCA: 3 Reconstituted Complex: 12 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Dosage Rescue: 6 Positive Genetic: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 5 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:432186 to 433373 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1188 432186..433373 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005583